Molecular Formula | C21H24N6O5 |
Molar Mass | 440.45 |
Storage Condition | 2-8°C,密封,干燥 |
biological activity | TNP-351 is an antifolate. TNP-351 is a dihydrofolate reductase (DHFR) inhibitor with potent antitumor activity against leukemia and solid tumor cells in vitro and in vivo. |
Target | Antifolate, DHFR |
Cell Line: | L1210 and CCRF-CEM cells |
Concentration: | 0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells |
Incubation Time: | 48 hours for L1210 cells; 72 hours for CCRF-CEM cells |
Result: | The ED 50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively. |